Reductive potential — A savior turns stressor in protein aggregation cardiomyopathy

Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice

The autosomal dominant mutation in the human alphaB-crystallin gene inducing a R120G amino acid exchange causes a multisystem, protein aggregation disease including cardiomyopathy. The pathogenesis of cardiomyopathy in this mutant (hR120GCryAB) is poorly understood. Here, we show that transgenic mice overexpressing cardiac-specific hR120GCryAB recapitulate the cardiomyopathy in humans and find ...

Reductive stress: linking heat shock protein 27, glutathione, and cardiomyopathy?

Normal cellular functions essentially depend on a balanced redox environment. Free radicals and nonradical oxidants can shift the redox balance toward a more “oxidized” state, which is counteracted by the intracellular antioxidant defense systems. These include the enzymes superoxide dismutase and catalase, as well as the thiol-reducing systems (glutathione, glutaredoxin, and thioredoxin). Glut...

Peripartum cardiomyopathy: when labour turns to heartbreak.

Lupus myopericarditis as a preceding stressor for takotsubo cardiomyopathy.

We describe herein a 61-year-old African American woman who presented with takotsubo cardiomyopathy preceded by lupus myopericarditis. The case highlights the importance of the association between pericarditis and takotsubo cardiomyopathy. This new stressor adds to the existing evidence that these two entities may coexist and do not have to be mutually exclusive.

Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells

Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway. The activation of Wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. In the nucleus, β-catenin interacts with the TCF/LEF transcription fa...